EPHB3 higher in CRC tissues than in normal mucosaEPHB3 declined during transformation from adenoma to carcinoma and as the tumor invaded into deeper tissuesBudding cancer cells at the invasive tumor fronts showed reduction of EPHB3 expressionEPHB3 expressed in 24% of 610 CRCsEPHB3 expression negatively associated with:○tumor differentiation○lympho-vascular invasion○TNM stageEPHB3 expression positively associated with MSIEPHB3 expression correlated with better clinical outcomes, but was not and independent prognostic marker. The gene discussed is EPHB3; the disease is carcinoma.