On the contrary, Wang et al [65] examined the mRNA expression of the two alternative isoforms of ephrin-A5, large ephrin-A5 (ephrin-A5L), and small ephrin-A5 (ephrin-A5S), through means of quantitative real-time PCR, reporting them lower in HCC compared with peritumoral tissues. Here, EFNA5 is linked to hepatocellular carcinoma.