Interestingly, when EPHB3 was expressed, redistribution of E-cadherin from the cytoplasm to the membrane was observed, revealing a possible mechanism through which EPHB3 might exert its speculated protective role, as E-cadherin membranous expression stabilizes cell to cell adhesion, decreasing tumor cells’ invasion capabilities, and disrupts EMT transition and cell proliferation. Here, EPHB3 is linked to neoplasm.