EPHB2 expressed in:○100% normal colon crypt base cells○78% adenomas○55.4% CRCs○37.8% LN metastasis○32.9% liver metastasisEPHB2 expression negatively correlated with:○tumor stage○poor differentiation○poor OS○poor DFSFrom tumor to metastasis, CRC carcinogenesis shows a progressive loss of EPHB2 expression. The gene discussed is EPHB2; the disease is neoplasm.