VPS35 and Alzheimer disease: Third, the gain of function of Vps35 in a triple transgenic AD mouse model, 3xTg-AD, which harbors a human mutant PSEN1 (M146V) knock-in, and mutant APP (KM670/671NL) and MAPT (P301L) transgenes, can fully reduce the AD-relevant phenotypes [24,30].