Notice that in this study, AAV-Vps35 (the Vps35 expression is under the control of synpasin-1 promoter) was bilaterally injected into the cerebral ventricles of the newborns of 3xTg-AD mice, and the AD-relevant brain phenotypes in 12 months-old-mice are diminished [24]. Here, VPS35 is linked to Alzheimer disease.