In addition to the neuronal terminal differentiation deficits and gliosis in Vps35Neurod6 mice, we also detected increases of P62/sequestosome 1 (SQSTM1), one factor that targets specific cargoes for autophagy, and Tdp-43, a DNA-RNA binding protein, in Vps35Neurod6 cortical neurons (Figure 4) [33,34,35,36], both proteins often associated with the pathology of FTD [21,37]. Here, TARDBP is linked to frontotemporal dementia.