TLR4 and age-related macular degeneration: The opposite effects of a SNP in a coding region of TLR4 have been studied, with TLR4 variant D299G (rs4986790) being associated with susceptibility to AMD in one study (in Caucasian subjects) [57], but not in follow-up studies (in Indian, Turkish, and Caucasian subjects) [42,43,49,58,59].