Genes associated with the IRT events described here are linked to a number of pathological conditions, including cancer (PSMB10, BAX, FES, PITPNM1, U2AF1L4, and CREB3L4), rheumatoid arthritis (RELB), nemaline myopathy 1 (ISYNA1), immunodeficiency (IRF7), diarrhea (DGAT1), nephrotic syndrome (COQ8B), Fundus dystrophy (ACBD4), glutaric acidemia I (GCDH), Charcot-Marie-Tooth disease (DENND2B), nephronophthisis (NEK8), non-syndromic intellectual disability (MROH6), and color blindness (RENBP). The gene discussed is CREB3L4; the disease is rheumatoid arthritis.