Importantly, many genes associated with the aberrant EIN events described here are linked to pathological conditions, including cancer (NAT1, NEMF, GMPR2, ENC1, MAP4K3, and EIF4A2), epilepsy (GABRE and DEPDC5), metabolic disorder (UGCG), schizophrenia/personality disorder (RAPGEF6), mental disorder (ATP6V1E2), retinitis pigmentosa (MPP5), keratosis (SAT1), hypertension (SFXN2), autism (ADNP), adult-onset Still’s disease (MAP4K3), and pulmonary disorder (CNNM3). The gene discussed is RAPGEF6; the disease is keratosis.