Genes associated with IRM events described here are linked to the following pathological conditions: cancer (APBB3, RREB1, RBM6, and MIR100HG), Fanconi anemia (CLK4, CCNL2, and TTLL3), cardiovascular defects (ACAD11, ZBTB21, ST3GAL1, and ARSJ), Noonan syndrome 1 (THUMPD1), neurological diseases (ATXN2L, MOK, MEG3, and CCDC14), metabolic disorders (ATXN2L, MEG3, and PLAGL1), and theileriasis (NKTR). This evidence concerns the gene PTPN11 and cancer.