First discovered in the ATXN8 gene which is involved in the Spinocerebellar ataxia 8 (SCA8), the products of RAN translation have been detected in vivo for other genes containing repetitive nucleotides such as Huntington’s disease (HD), myotronic dystrophy type 1 and 2 (DM1, DM2), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [44]. Here, ATXN8 is linked to amyotrophic lateral sclerosis.