IRF2BPL and fragile X-associated tremor/ataxia syndrome: Importantly, FXTAS patients showed the downregulation of Interferon Regulatory Factor 2 Binding Protein-like (IRF2BPL)/Early at Puberty 1 (EAP1), firstly described as a neuronal transcriptional regulator of female reproductive function [177] and later associated with the neurodevelopmental epileptic encephalopathy NEDAMSS (neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures, OMIM #618088) [178,179] that was also exacerbated in FXPOI patients compared to asymptomatic PM women [76].