CS and fragile X-associated tremor/ataxia syndrome: Noticeably, ROS production and mitochondrial function (e.g., citrate synthase activity, ATP production, etc.)in lymphocytes showed significant correlations with clinical outcomes in a cohort of PM women, such as diagnosis of FXTAS and FXTAS stage, diagnosis of FXPOI, number of CGG repeats, anxiety and full-scale IQ [79], suggesting that peripheral bioenergetics is directly linked to Fragile X-associated symptomatology.