TRPM1 and melanoma: Interestingly, while, as expected, melanocytes (adult and neonatal) showed little expression of these three genes, but high expression of TRPM1 (Figure 11, first row), all primary melanoma lines—including IGR39—showed a decreased expression of TRPM1 and highly increased expression of KCNMA1 and TRPM2, and also of KCNN4 in three out of four (Figure 11, second row).