Taken together, given that the impairment of glutamatergic activity particularly in the mesolimbic pathway affects schizophrenic behaviors [68,69,154,155,156,157,158], it is postulating that NBCn1 and NDCBE play a role in schizophrenia by altering glutamate release or NMDA receptor activity. The gene discussed is SLC4A7; the disease is schizophrenia.