Taken together, given that the impairment of glutamatergic activity particularly in the mesolimbic pathway affects schizophrenic behaviors [68,69,154,155,156,157,158], it is postulating that NBCn1 and NDCBE play a role in schizophrenia by altering glutamate release or NMDA receptor activity. This evidence concerns the gene SLC4A8 and schizophrenia.