TNF-α appears to be the master regulator of bone loss in IBD as it promotes expression of receptor activator of nuclear factor κB ligand (RANKL) from osteogenic cells and independently interacts with RANKL as a potent stimulator of osteoclastogenesis, via the nuclear factor kappa B (NF-κB) signaling pathway [19,20]. Here, TNFSF11 is linked to inflammatory bowel disease.