Regarding the flavonoids found in EA-Aa, quercetin (3,5,7-trihydroxy-2-(3,4-dihydroxyphenyl)-4Hchromen-4-one) was also associated to hypoglycaemic mechanisms [32] such as higher levels of insulin receptor (IR) and insulin receptor substrate (IRS), besides GLUTs and the inhibition of α-glucosidase activity, which are associated to the improvement of insulin resistance [37]. Here, IARS1 is linked to Insulin resistance.