TMPRSS2 and lung cancer: In Figure 4, treatments with HT and HD repressed the protein expressions of ACE2 and TMPRSS2 in normal lung epithelial Beas 2B cell (Figure 4A) and in H460 lung cancer cells (Figure 4B), suggesting that HT and HD not only disrupted the interaction of ACE2 and SARS-CoV-2 S protein but also inhibited the protein expressions of ACE2 and TMPRSS2 for the reduction of SARS-CoV-2 infection.