ACE2 and Huntington disease: More recently, HD has been shown to possess the anti-SARS-CoV-2 infection activity in an in vitro cell line model [17], and is predicted to bind to viral S and 3CLpro proteins of SARS-CoV-2 and cellular ACE2 of host cells in the molecular simulation analysis [18,19], implying the anti-SARS CoV-2 potential of HD.