On the other hand, maintaining regular meal timing and following strategies such as time-restricted eating (TRE), in which the time from the first meal to the last meal in a day is restricted to a period of 8–12 h, have been reported to improve circadian clock oscillation, obesity, pre-type 2 diabetes, and cognitive function [21,22]. Here, CLOCK is linked to obesity due to melanocortin 4 receptor deficiency.