The administration of jujube powder altered the gut microbiota significantly, as evidenced by the recovery of the alpha diversity index in terms of Shannon and Simpson index (Figure 2A), increased CD8+ T cells in peripheral blood (Figure 6D) and tumor microenvironment (Figure 1C), inhibited eosinophilia (Figure 6B), and enhanced the effectiveness of CTX on MC38 colon cancer (Figure 1A). The gene discussed is CD8A; the disease is colonic neoplasm.