The implementation of the lifestyle interventions for 1 year, particularly given the high rate of good compliance, also resulted in a significant improvement in clinical (BMI, BMI z-score and waist to height ratio) and body composition indices of obesity (fat percentage, muscle mass, fat free mass, and total body water), inflammatory markers (WBC, platelets, ferritin), hepatic enzymes (AST, ALT, γ-GT), HbA1C, QUICKI index, and lipid profile (HDL, LDL, ApoA1, ApoB) in all participants. This evidence concerns the gene APOB and obesity due to melanocortin 4 receptor deficiency.