In addition to these changes, in the microbiota from patients and animal models of SLE takes place a pathophysiological process in the epithelium of the intestinal barrier characterized by impairment in junction proteins like occludin, ZO-1 and claudin, and a higher intestinal permeability, as determined by fluorescein isothiocyanate (known as FITC-dextran) [42]. Here, TJP1 is linked to systemic lupus erythematosus.