Since immunomodulatory probiotics have been effective in the treatment of SLE in other models that also present dysbiosis [23], the objective of the present experiment was to elucidate if Lactobacillus fermentum CECT5716 (LC40) and/or Bifidobacterium breve CECT7263 (BFM) can prevent hypertension, endothelial dysfunction and intestinal dysbiosis in a murine lupus model inducible by epicutaneous administration of the TLR7 agonist imiquimod (IMQ). This evidence concerns the gene TLR7 and Hypertension.