JAK2 and coronary artery disorder: It has been also reported that each of DNA methyltransferase 3A (DNMT3A), ten-eleven translocation-2 (TET2), additional sex combs-like 1 (ASXL1), and Janus kinase 2 (JAK2) mutation was associated with coronary artery disease, and that CHIP carriers with these mutations also had high levels of coronary artery calcification [9].