It was noteworthy that ASBs intake was found to be not accompanied by typical and expected post-ingestive consequences, such as the release of insulin after meals, and therefore, this might degrade the capacity of sweet tastes to evoke these responses, resulting in higher blood glucose levels and more consequences, such as obesity, metabolic syndromes, and diabetes [23,76,77]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.