INS and Hypoglycemia: Therefore, the aim of this study was to test the effects of dietary ketosis, induced by a 3 week KD, on components of the sympathoadrenal CRR to severe insulin-induced hypoglycemia in healthy, nondiabetic rats, by measuring adrenal sympathetic nerve activity (ASNA), adrenal gland activity, and epinephrine release, as well as the activation state of catecholaminergic C1 neurons in the brainstem, which are glucose-sensitive and involved in the hypoglycemic CRR [23,24].