Insulin-induced hypoglycemia significantly increased Fos immunoreactivity in both Chow-fed rats (23.6 ± 4.8%, p = 0.0001, Figure 7a,e) and KD-fed rats (20.9 ± 1.8%, p = 0.0007, Figure 7b,e). This evidence concerns the gene INS and Hypoglycemia.