INS and Hypoglycemia: Here, we report that a 3 week KD in rats (1) induces stable ketosis, (2) does not impair the counterregulatory epinephrine release in response to severe insulin-induced hypoglycemia, (3) does not diminish the sympathoadrenal response as assessed by adrenal sympathetic nerve activity and adrenal gland function, and (4) shifts the onset of sympathoadrenal counterregulatory response to lower blood glucose levels.