Baseline BHB levels in the Chow-fed rats were substantially lower in both cerebral and peripheral blood (1.6 ± 0.4 mmol/L and 1.4 ± 0.3 mmol/L, respectively) compared to the KD-fed rats, and the hypoglycemia-induced decrease was modest, reaching the lowest of 0.5 mmol/L at 60 min post insulin injection (Figure 4b). The gene discussed is INS; the disease is Hypoglycemia.