APOA1 and type 2 diabetes mellitus: For instance, cranberry juice has been shown to significantly increase high-density lipoprotein-cholesterol (HDL-C) in adults with abdominal obesity [13], reduce triglycerides in healthy adults [14], and reduce apolipoprotein B while increasing apolipoprotein A-I in patients with type 2 diabetes [15]; however, these effects were not observed in other studies of cranberry juice [16,17,18] and cranberry extracts [19].