Caffeic acid phenylethyl ester has been shown to inhibit the S6 beta-1 ribosomal protein kinase (p70S6K), an intermediary responsible for protein synthesis in the PI3K/AKT pathway and some AKT signaling networks, leading to inhibition of proliferation of prostate cancer cells LNCaP, DU-145, and PC-3 [3]. This evidence concerns the gene AKT1 and Familial prostate cancer.