Caffeic acid phenylethyl ester has been shown to inhibit the S6 beta-1 ribosomal protein kinase (p70S6K), an intermediary responsible for protein synthesis in the PI3K/AKT pathway and some AKT signaling networks, leading to inhibition of proliferation of prostate cancer cells LNCaP, DU-145, and PC-3 [3]. The gene discussed is AKT1; the disease is prostate cancer.