FDFT1 and colorectal cancer: Short and longer time fasting upregulated in both in vitro cell and in vivo animal study the expression of farnesyl-diphosphate farnesyltransferase 1 (FDFT1), which acts as a critical tumor suppressor in colorectal cancer by negatively regulating Akt–mTOR–hypoxia inducible factor-1α (HIF1α) signaling and, therefore, resulted in slower tumor growth [209].