HMGCS1 and neoplasm: It has been recognized that SREBP2 is the classic controller for cholesterol de novo synthesis gene activation [45,46,47], including HMGCS1. Our previous studies revealed that the NR RORγ exhibits a predominant action over that of SREBP2 in programming cholesterol biosynthesis in tumor cells [22] and in porcine liver organoids [28], respectively, which is in agreement with our present findings.