MMP7 and obesity due to melanocortin 4 receptor deficiency: While ovariectomy induced obesity and triggered dysbiosis [66], we observed little changes in the mRNA expression levels of genes involved in epithelial cell differentiation and permeability throughout the gut segments with the exception of fatty acid transporters (Cd36 and Got2), Mmp7 in the jejunum, Muc2 in the ileum, and Tjp1 and Atoh1 in the colon.