Here, the WHO recommendation on physical activity and sedentary behavior should be strongly considered to achieve benefits in children and adolescents for improved physical fitness (cardiorespiratory and muscular fitness), cardiometabolic health (blood pressure, glucose, and insulin resistance), bone health, cognitive outcomes (academic performance, executive function), mental health (reduced symptoms of depression), and reduced obesity [54]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.