Hypoxic exosomes was found to be enriched with proteins such as protein-lysine 6-oxidase (LOX), thrombospondin-1 (TSP1), and VEGF, and a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), which are well-studied contributors to tumor progression, metastasis, and angiogenesis [127]. The gene discussed is THBS1; the disease is neoplasm.