PRNP and Alzheimer disease: For example, the formation of amyloid fibrils associated with Alzheimer’s disease (AD) by peptide misfolding and aggregation [58,59]; Parkinson’s disease (PD) associated with Lewy bodies composed of α-synuclein [60,61]; and Extensive Transmissible Spongiform Encephalopathy (TSEs) caused by foreign or their own genetic mutations, causing human normal type C prion protein (PrPc) to misfold into type SC prion protein (PrPsc) [62,63].