Accordingly, our study has first verified a newly designed experimental model of neuroinflammation that resembles sporadic AD, using LPS in rats fed high fat/high fructose diet (HFFD); then, we have used this model to investigate the potential neuroprotective impact of the post-administration of palonosetron with or without methyllycaconitine (MLA), to assess the role of α7nAChR in the 5-HT3 blocker effect. This evidence concerns the gene CHRNA7 and Alzheimer disease.