Delicaflavone, a novel anticancer agent, a biflavonoid from Selaginella doederleinii Hieron, induced ROS accumulation and inhibited the PI3K/Akt/mTOR signaling pathway, demonstrating the importance of studying ROS and the PI3K/Akt/mTOR pathway in the context of cancer [53]. This evidence concerns the gene AKT1 and cancer.