NLRP3 and cryopyrin-associated periodic syndrome: Dapansutrile (OLT1177) is chemically a β-sulfonyl nitrile compound that has been demonstrated to suppress NLRP3-mediated IL-1β secretion from LPS stimulated PBMCs of cryopyrin-associated periodic syndrome (CAPS) patients and primary human neutrophils exemplifying the interception of IL-1β alteration in a classic NLRP3 gain-of-function disease [27,28].