Curcumin has been documented to have salutary effects in various murine models with scrutiny of NLRP3-driven associations like high-fat diet (HFD)-induced insulin resistance and MSU-induced peritoneal inflammation [188], chronic kidney disease [189], potassium oxonate-induced hyperuricemia and kidney inflammation [190], LPS-evoked septic shock [191], diabetic nephropathy [192], lupus [193], and dextran sulfate sodium (DSS)-induced colitis [194]. The gene discussed is NLRP3; the disease is colitis.