While IL-1β secretion from wild-type mouse BMDM was roughly 50% at 20 μM concentration of the 16673-34-0 crossbreed, the effect was markedly blunted in macrophages carrying NLRP3-activating mutations usual of NLRP3-selective genetic disorders like Muckle–Wells. This evidence concerns the gene NLRP3 and hereditary disease.