Researchers have come to ground-breaking conclusions on the modulation of gene transcription or protein expression effects of NLRP3 inflammasome signaling cascade operating through NEK7 effects in NLRP3-associated maladies, like tumors, inflammatory diseases, and autoimmune diseases, such as squamous cell carcinoma of head and neck, hepatocellular carcinoma, diabetic retinopathy, systemic lupus erythematosus, gout, atherosclerosis, type 2 diabetes, metabolic syndrome, age-related macular degeneration, Alzheimer’s disease, multiple sclerosis, and inflammatory bowel disease [260,261]. The gene discussed is NLRP3; the disease is hepatocellular carcinoma.