In line with this study, ref. [58] found that the curcumin loaded poly lactic-co-glycolic-acid nanoparticles, when targeted to the neuroblastoma cell line for the treatment of Alzheimer’s Disease, showed inhibition of nuclear factor erythroid 2 related factor (Nrf2) which is a natural protein, thereby stopping oxidative damage of the cells. Here, NFE2L2 is linked to early-onset autosomal dominant Alzheimer disease.