Sacubitril/valsartan, valsartan, resveratrol, and sacubitril/valsartan + resveratrol also significantly reduced the levels of TNF-α in MI-induced rats compared to MI-induced rats treated with vehicle (Figure 4B. 5.33±0.31 vs. 3.45 ± 0.45, 3.52 ± 0.28, 3.68 ± 0.64, and 3.07 ± 0.61, p < 0.05). The gene discussed is TNF; the disease is myocardial infarction.