Concerning the exogenously-induced activation of Nrf2, several well-known Nrf2 activators (described in Section 3.3) have displayed neuroprotective effects in ischemic stroke models and, notably, some Nrf2-activating compounds had superior neuroprotective effects against IRI in wild-type compared to Nrf2 knockout animals [89,151]. Here, NFE2L2 is linked to ischemic stroke.