Based on an IR protocol with a luciferase mouse model (a Keap1-dependent oxidative stress detector to visualize the Nrf2 expression from brain ischemia), Takagi and collaborators [82] showed increased levels of Nrf2 in the cerebral cortex and striatum of mice subjected to transient middle cerebral artery occlusion. Here, NFE2L2 is linked to brain ischemia.