EGFR and neoplasm: It was previously mentioned by Aly et al. (see Scheme 23) [60] that 5-amino-1-(1-ethyl-2-oxo-1,2-dihydroquinolin-4-yl)-1H-pyrazole-3,4-dicarbonitrile 56 showed a good antiproliferative EGFR-TK inhibition activity against many tumor cell lines.