NOS3 and diabetes mellitus: Endothelial dysfunction associated with eNOS uncoupling which leads to the production of ROS has been reported both in animal models such as angiotensin II-induced hypertension [70], streptozotocin (STZ)-induced diabetes [71], and hypertension-induced heart failure [72] as well as in patients with diabetes, hypertension, hypercholesterolemia, and atherosclerosis [73].