NFKB1 and hepatocellular carcinoma: In contrast to OAO conjugates with ASP, OAO hybrids with indomethacin and diclofenac reduced activation and expression, not only NF-κB, but also Nrf2 in hepatoma cells, while in normal cells, increased activation of Nrf2 was still observed (Figure 3 and Figure 4) [39,62].