Regarding the mechanisms of cordycepin enhancing cisplatin anti-cancer activity, we demonstrated the activation of c-Jun N-terminal kinase (JNK) and caspase pathways in head and neck tumor cells [56,57] and the activation of JNK, p38, p53, and caspase pathways in MA-10 cells [58]. Here, MAPK8 is linked to head and neck neoplasm.