Among the few studies that observed cordycepin-induced cell death through autophagy in different cancer cells [21,49,51,52,53], mechanism descriptions were brief and described that cordycepin could trigger an increase in the LC3-II to LC3-I protein ratio, inhibition of the β-catenin pathway, and/or the suppression of the mechanistic target of rapamycin (mTOR) signaling pathway (Figure 1). This evidence concerns the gene MTOR and cancer.