Various studies on the anti-cancer effects of cordycepin has been described [16,26,27,28], and the mechanisms through which cordycepin kills tumor cells and suppresses tumor growth have been studied and summarized to show that cordycepin may induce tumor cell death through cysteine–aspartic proteases (caspases), mitogen-activated protein kinase (MAPK), and glycogen synthase kinase (GSK)-3β pathways mediated by putative adenosine receptors, death receptors, and/or epidermal growth factor receptors (EGFR) [16,27,29]. The gene discussed is EGFR; the disease is neoplasm.