SQSTM1 and systemic lupus erythematosus: In contrast to pre-B and mature B1a B cell survival, a correlation analysis showed that the expression levels of apoptotic proteins, including Beclin-1, LC3, and p62, are positively correlated with the systemic lupus erythematosus disease activity index, which can evaluate the disease activity of systemic lupus erythematosus [149,150].