The down-regulation of anti-apoptotic gene products such as B-cell lymphoma 2 (Bcl-2) (Figure 3), X-linked inhibitor of apoptosis (XIAP), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) may be implicated to mediate the anti-cancer effects [49,50]. The gene discussed is PTGS2; the disease is cancer.