Interestingly, while the TauTKO mice developed by the Warskulat’s group showed normal cardiac function, the expression of fetal genes such as ANP, BNP and CARP (cardiac ankyrin repeat protein) increased in the TauTKO hearts, suggesting taurine depletion may predispose the mice to the development of a heart failure [127]. The gene discussed is NPPA; the disease is heart failure.