Hence, the study objectives were that in two hindlimb muscles, namely gastrocnemius and soleus, of lung cancer (LC) cachectic mice treated with either curcumin or resveratrol for 15 consecutive days: (1) limb muscle strength and weight, (2) muscle fiber type and morphometry, (3) muscle structural abnormalities, (4) sirtuin-1 and muscle-specific protein content, (5) proteolytic markers including troponin I, and (6) signaling mechanisms were examined. Here, SIRT1 is linked to laryngotracheoesophageal cleft.