Particularly, miR-34a has been confirmed to be a well-defined tumor suppressor which could persuade the cell apoptosis, the cell cycle arrest at G1 phase and also restrain the migration of tumor cells by decreasing the expression of Bc1-2, Notch-1, survivin, CD44 and the cyclin family [9,10,11,12,13]. This evidence concerns the gene NOTCH1 and neoplasm.