Curcumin-loaded exosomes were intranasally administrated in three inflammation-mediated disease models, an LPS-induced brain inflammation model, experimental autoimmune encephalitis, and a GL26 brain tumor model protected from LPS-induced brain inflammation; the progression of myelin oligodendrocyte glycoprotein peptide induced experimental autoimmune encephalomyelitis and had significantly delayed brain tumor growth in the GL26 tumor model without observable side effects [126]. The gene discussed is MOG; the disease is brain inflammatory disease.