As shown in Figure 3D,E, phycocyanin and IRS-1 siRNA treatment both reduced the phosphorylation levels of AKT proteins in A549, H1299, and LTEP-a2 cells, indicating phycocyanin might inhibit proliferation and migration of NSCLC cells through downregulating IRS-1/AKT activities. Here, IRS1 is linked to non-small cell lung carcinoma.