CD40LG and infection: In one retrospective study conducted on 150 newborns of whom 28 (18.7%) were symptomatic at birth, it was shown that the risk of symptomatic cCMV at birth increased linearly with the number of significant maternal (gestational age at infection), fetal (viral DNA levels in blood and amniotic fluid, and IgM antibody level) and neonatal (DNAemia) parameters [79].