ACE2 and heart failure: A previous work showed that patients with heart failure had higher ventricular ACE2 expression levels and a recent study with RNA sequencing revealed that myocardial ACE2 expression was significantly increased in patients with heart failure (fold change = 3.00, p < 0.0001), which was further validated at the protein level by proteomics profiling (fold change = 1.82, p < 0.0001) [16,71].