ALB and neoplasm: In addition, Nakamura et al. developed a boron compound, maleimide-functionalized closo-dodecaborate (MID), which can be introduced into cysteine [211], and focused on the phenomenon that stained serum albumin accumulates in tumor tissue (EPR effect), maleimide-functionalized closo-dodecaborate albumin conjugates (MID-AC) was prepared by binding MID to serum albumin and verified the antitumor effect of BNCT using cancer transplant mice [212].