Interestingly, SS-31 a compound that specifically targets the mitochondrial phospholipid cardiolipin [66] was also shown to lower diabetes-induced CD36 expression in db/db mice and to improve high glucose-induced CD36 expression and lipid deposition in HK-2 cells, suggesting that the protective effect of SS-31 on renal function is associated with the suppression of CD36 expression [67]. Here, CD36 is linked to diabetes mellitus.