COL4A3 and kidney disorder: In another study, we demonstrated that promoting ABCA1-mediated cholesterol efflux similarly prevents renal disease progression in an experimental model of FSGS (adriamycin-induced nephropathy) and of Alport syndrome (Col4a3 KO mice) in association with reduced formation of lipid droplets in glomeruli and reduced accumulation of cholesterol esters in kidney cortices.