For instance, Tangier disease is a rare autosomal recessive disorder associated with mutations in the ATP-binding cassette subfamily A member 1 (ABCA1) [16], and patients with the disease present with a decrease in high-density lipoproteins (HDL), accumulation of cholesterol esters in multiple organs, mild proteinuria and foamy podocytes in kidney biopsies [17]. The gene discussed is ABCA1; the disease is Tangier disease.