It is newsworthy that HMGA2 and H-RAS oncogenes are targeted by an induced expression of let-7 in breast cancer cells, and in a murine model of breast cancer, exogenous let-7 delivery represses mammosphere formation, cell proliferation, and the undifferentiated cell population by downregulating both H-RAS and HMGA2 oncogenes [27]. Here, HRAS is linked to breast cancer.