Six out of the 19 TFs, namely ETS Proto-Oncogene 1, Transcription Factor (ETS1), Fos Proto-Oncogene, AP-1 Transcription Factor Subunit (FOS), Jun proto-oncogene, AP-1 transcription factor subunit (JUN), JunD Proto-Oncogene, AP-1 Transcription Factor Subunit (JUND), NFKB Inhibitor Alpha (NFKBIA), and TNF Alpha Induced Protein 3 (TNFAIP3) from the co-regulatory network are present in the RA map. This evidence concerns the gene ETS1 and rheumatoid arthritis.