After adjusting for the significant variables in the univariable analysis (Table 2), old age, hypertension, diabetes mellitus, high systolic blood pressure, high fasting glucose, high uric acid, low hemoglobin, high baseline eGFR, low albumin (odds ratio [OR], 0.173; 95% confidence interval [CI], 0.127 to 0.236; p < 0.001), high AFP (OR, 1.006; 95% CI, 1.001 to 1.011; p = 0.010), and low total bilirubin (OR, 0.588; 95% CI, 0.439 to 0.786; p < 0.001) were significantly associated with an eGFR decline of ≥25%. This evidence concerns the gene AFP and diabetes mellitus.