After adjusting for the significant variables in the univariable analysis (Table 2), hypertension, diabetes mellitus, high systolic blood pressure, high heart rate, high fasting glucose, low hemoglobin, high baseline eGFR, low albumin (OR, 0.189; 95% CI, 0.130 to 0.274; p < 0.001), high AFP (OR, 1.007; 95% CI, 1.002 to 1.012; p = 0.011), and low total bilirubin (OR, 0.569; 95% CI, 0.405 to 0.801; p = 0.001) were significantly associated with an eGFR of decline ≥25% in the male participants with GPT of ≤35 μ/L and female participants with GPT of ≤25 μ/L. This evidence concerns the gene AFP and diabetes mellitus.