Second, we examined the global gene expression profiles for 33 patients; nine of which showed a generally higher mediator release after chloroquine exposure, and these patients showed leukemic cell upregulation of several genes (SNX2, FLT3, PFKP, and CCL23) involved in AML leukemogenesis (Figure S4). The gene discussed is FLT3; the disease is acute myeloid leukemia.