TNF and diabetes mellitus: The possible confounders for IL-1beta, TNF-alpha were represented by chronic pathologies that influence the inflammatory status: chronic infections, chronic autoimmune disorders, diabetes, neoplasms, but as they were present before and after implantation, their impact was more likely to be low, a higher variation of the inflammatory marker values might have been induced by acute decompensations of these chronic conditions, and some of these might even not be identified.