The possible confounders for IL-1beta, TNF-alpha were represented by chronic pathologies that influence the inflammatory status: chronic infections, chronic autoimmune disorders, diabetes, neoplasms, but as they were present before and after implantation, their impact was more likely to be low, a higher variation of the inflammatory marker values might have been induced by acute decompensations of these chronic conditions, and some of these might even not be identified. The gene discussed is IL1B; the disease is diabetes mellitus.